A study published in the scientific report found that the combination of CBD (cannabinoids) and antibiotics was more effective than antibiotics alone. This means that a certain number of bacteria can be killed, with the participation of CBD, and fewer antibiotics can be used, which proves that CBD may be a breakthrough to solve antibiotic resistance.
In the study conducted at the University of Southern Denmark, the researchers used CBD (cannabinoids) as a potential "helper compound" of the antibiotic bacitracin to help kill "Gram-positive bacteria".
"Gram positive bacteria" and "gram negative bacteria" are two kinds of bacteria identified by Gram staining. Most of the "pyogenic cocci" belong to Gram-positive bacteria, they can produce exotoxins to make people sick, while most of the intestinal bacteria belong to Gram-negative bacteria, they produce endotoxin, which makes people sick.
First of all, the researchers confirmed the killing effect of CBD and antibiotic bacitracin on four Gram-positive bacteria, including Staphylococcus aureus (MRSA), Enterococcus faecalis, Listeria monocytogenes and MRSE.
By controlling the dosage of CBD, the researchers further confirmed that CBD has an antibacterial enhancing effect on the killing of "Gram-positive bacteria" by antibiotics "bacitracin", and also pointed out that it has no such enhancing effect on "Gram-negative bacteria".
Then, the researchers used "Staphylococcus aureus" to further study the mechanism of CBD enhancing the effect of antibiotics. It was observed that when CBD was used as an auxiliary compound, "Staphylococcus aureus" would no longer divide as usual, the expression of key genes in bacteria would also be reduced, the bacterial membrane became unstable, and these changes of "Staphylococcus aureus" reduced the number of antibiotics needed for treatment.
Janne kudsk klitgaard, one of the study's authors, said that combining antibiotics with ancillary compounds, such as CBD, could reduce the total amount of antibiotics used, which "helps reduce the development of resistant bacteria.".
Antibiotics are considered one of the greatest medical advances of all time. If it wasn't for antibiotics, people could have died of pneumonia or simple wound infections.
However, less than a hundred years after the application of antibiotics, bacteria have produced various mechanisms, changed the way of response to antibiotics, and the "resistance" to antibiotics has been increasing. Many different infections, including tuberculosis, pneumonia, blood poisoning, gonorrhea, foodborne pathogens, have become increasingly difficult to treat.
Antibiotics resistant bacteria spread rapidly, the resistant bacteria were not killed by some antibiotics, then they were not restricted, and even passed the resistance to other bacteria.
The problem of antibiotic resistance has become more and more a difficult problem in the world. According to a report released by the World Health Organization, by 2050, due to the resistance of bacteria to antibiotics, 10 million people will die every year, equivalent to one person lost life every three seconds, which will cause more harm than cancer. At the same time, the most worrying is that the harm is increasing year by year.
The biggest factor of antibiotic resistance is abuse and overuse of these drugs. In many countries, access to antibiotics does not require a prescription, and abuse can occur even if access to antibiotics from a doctor is required. Some patients stop using once they feel good, the bacteria may not be completely killed, and then they will start to mutate.
Staphylococcus aureus (MRSA) is a very well-known drug-resistant bacteria, which is the cause of many difficult to treat infections.
In this study at the University of Southern Denmark, the researchers used CBD as an "auxiliary compound" of antibiotics, and found its beneficial effect on antibiotics.
In previous studies, some researchers believed that CBD is an effective antibiotic and an antibiotic that will not produce resistance.
Last year, according to Newsweek, Australian researchers found that CBD can kill a group of bacterial strains, which are also a group of "Gram-positive bacteria", including "Staphylococcus aureus" and "Enterococcus faecalis". And even if they were exposed to CBD for 20 days (when bacteria can be resistant to antibiotics), they would not be resistant to CBD.
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